Zhang W G, Ma A Q, Wei J, Feng Q M, Liu Z Q
Department of Cardiology, First Affiliated Hospital Xian Medical University, China.
Blood Press Suppl. 1996;3:45-8.
The frequency, dynamical change and effects of autoantibodies against the adenine nucleotide translocator (ANT) in idiopathic dilated cardiomyopathy (IDC) were studied. Sera of 16 patients with IDC showed significant binding capacity to the ANT protein (33.3%). Anti-ANT antibody titre was gradually tapered in approx. 2-3 months duration. However, anti-ANT antibody can inhibit the ADP/ATP exchange of heart mitochondria and be organ-specific. Short-term (6 weeks) treatment of 15 anti-ANT antibody-positive IDC patients with prednisone was of beneficial effect. Our results show that autoimmunity to the ANT can contribute to the pathogenesis and/or progression of IDC to a certain extent. But we must pay more attention to the fact that anti-ANT antibody characteristically exists short-term. Therefore, a short-term immunosuppressive treatment should be given to those IDC patients whose anti-ANT antibody is positive.
研究了特发性扩张型心肌病（IDC）中抗腺嘌呤核苷酸转位酶（ANT）自身抗体的频率、动态变化及其影响。16例IDC患者的血清显示出对ANT蛋白的显著结合能力（33.3%）。抗ANT抗体滴度在约2 - 3个月的时间内逐渐下降。然而，抗ANT抗体可抑制心脏线粒体的ADP/ATP交换，且具有器官特异性。对15例抗ANT抗体阳性的IDC患者进行短期（6周）泼尼松治疗具有有益效果。我们的结果表明，针对ANT的自身免疫在一定程度上可促进IDC的发病机制和/或进展。但我们必须更加关注抗ANT抗体具有短期存在这一特点。因此，对于抗ANT抗体阳性的IDC患者应给予短期免疫抑制治疗。
