Paterna S, Di Pasquale P, Montaina G, Procaccianti P, Antona A, Scaglione R, Parrinello G, Martino S, Licata G
Istituto di Patologia Medica, Università degli Studi, Palermo.
Cardiologia. 1991 Oct;36(10):811-5.
In the present study the effects of heroin and morphine administration on cardiac function, myocardial enzyme activity and cardiac ultrastructure features have been evaluated in isolated and perfused rabbit hearts. In 24 male rabbits the hearts were excised and immediately perfused in a retrograde non recirculating Langendorff apparatus. Successively, heroin 1 x 10(-5) or 1 x 10(-4) M or morphine at 1 x 10(-4) M were individually administered in 18 rabbits for 45 min. In 6 rabbits, used as controls, the isolated hearts were perfused with perfusion fluid for the same time. At the end of perfusion period the hearts were removed and histology was studied. During the perfusion period, creatine phosphokinase (CPK), lactic dehydrogenase (LDH) activity, heart rate (HR), derivative of intraventricular pressure time ratio (dP/dt) and changes in systolic ventricular pressure (SVP), diastolic ventricular pressure (DVP) and in coronary blood flow (CBF) were also evaluated. At the end of perfusion period no significant changes in CPK, LDH, HR, dP/dt ratio, SVP, DVP and CBF in comparison with basal values were observed in all groups. Histological specimen were characterized by slight derangements in atrial and ventricular structure both after heroin and after morphine administration. In conclusion our data suggest that alterations following opioids administration might rather be related to a systemic action involving only indirectly the heart.
在本研究中，已在离体灌注的兔心脏中评估了给予海洛因和吗啡对心脏功能、心肌酶活性及心脏超微结构特征的影响。将24只雄性兔的心脏取出，立即在逆行非循环的Langendorff装置中进行灌注。随后，在18只兔中分别给予1×10⁻⁵或1×10⁻⁴ M的海洛因或1×10⁻⁴ M的吗啡，持续45分钟。在6只用作对照的兔中，将离体心脏用灌注液灌注相同时间。灌注期结束时取出心脏并进行组织学研究。在灌注期内，还评估了肌酸磷酸激酶（CPK）、乳酸脱氢酶（LDH）活性、心率（HR）、室内压时间比值的导数（dP/dt）以及收缩期心室压（SVP）、舒张期心室压（DVP）和冠状动脉血流量（CBF）的变化。灌注期结束时，所有组与基础值相比，CPK、LDH、HR、dP/dt比值、SVP、DVP和CBF均未观察到显著变化。组织学标本显示，给予海洛因和吗啡后，心房和心室结构均有轻微紊乱。总之，我们的数据表明，阿片类药物给药后的改变可能更多地与一种仅间接涉及心脏的全身作用有关。
