Newlin D B
NIDA Intramural Research Program, Baltimore, MD, USA.
Drug Alcohol Depend. 1995 Mar;37(3):211-6. doi: 10.1016/0376-8716(94)01086-z.
This paper discusses a distinct cardiovascular pattern that is common to a wide variety of abused substances. The pattern consists of tachycardia that appears mediated by withdrawal of vagal inhibition, as indicated by decreases in cardiac vagal tone. This decrease in vagal tone was particularly robust with i.v. cocaine given to experienced cocaine abusers in a residential research setting. Following 40 mg i.v. cocaine, heart rate increased by approximately 30 beats/min at the same time that vagal tone decreased by approximately 2 log units. The theoretical significance of these findings is based on evidence that the results reflect a common factor among many abused drugs, but not the few aversive drugs that have been studied in this paradigm.
本文讨论了一种独特的心血管模式，这种模式在多种滥用物质中很常见。该模式包括心动过速，这似乎是由迷走神经抑制的解除介导的，心脏迷走神经张力降低表明了这一点。在住院研究环境中，给有经验的可卡因滥用者静脉注射可卡因时，迷走神经张力的这种降低尤为明显。静脉注射40毫克可卡因后，心率增加约30次/分钟，同时迷走神经张力降低约2个对数单位。这些发现的理论意义基于这样的证据，即结果反映了许多滥用药物中的一个共同因素，而不是在此范式中研究过的少数厌恶药物中的因素。
