酒精对心率影响的迷走神经介导作用。

Vagal mediation of the effect of alcohol on heart rate.

作者信息

Newlin D B, Byrne E A, Porges S W

机构信息

Purdue University, West Lafayette, Indiana.

出版信息

Alcohol Clin Exp Res. 1990 Jun;14(3):421-4. doi: 10.1111/j.1530-0277.1990.tb00498.x.

DOI:10.1111/j.1530-0277.1990.tb00498.x

PMID:2378426

Abstract

Alcohol (0.5 g/kg bodyweight) was administered in two sessions and placebo in a third session to normal, healthy social drinkers. A control group was administered a mixer (i.e., no alcohol) for each of the three sessions. The heart rate and vagal tone index (V) response patterns were different to alcohol than to the mixer or placebo. The treatments did not differentially influence pulse transit time. The results indicated that the acute effect of a moderate dose of alcohol on the heart is parasympathetically (i.e., vagally) mediated and has no significant direct sympathetic component.

摘要

对正常、健康的社交饮酒者分两次给予酒精（0.5克/千克体重），第三次给予安慰剂。对照组在三次实验中每次都给予混合饮料（即不含酒精）。酒精与混合饮料或安慰剂相比，心率和迷走神经张力指数（V）的反应模式有所不同。这些处理对脉搏传输时间没有差异影响。结果表明，中等剂量酒精对心脏的急性作用是由副交感神经（即迷走神经）介导的，且没有显著的直接交感神经成分。