Bruch K, Haas J
Ann Trop Med Parasitol. 1976 Jun;70(2):205-11. doi: 10.1080/00034983.1976.11687113.
Fenbendazole (Hoe 881) 5-(phenylthio)-2-benzimidazolecarbaminicacidmethylester in doses of 1-0 g and 1-5 g per person were effective against Ascaris and gave substantial egg count reductions against hookworm (mainly Necator americanus). The 1-5 g dose gave good results against Trichuris. In a trial with a suspension of Hoe 881 with a high specific surface of 25 m2/g there was no advantage over tablets with a specific surface of approximately 8 m2/g. Two doses of 500 mg given with an interval of 24 hours were no more effective than one dose of 1-0 g. In a comparative trial using Hoe 881 1-5 g, Pyrantel 10 mg/kg and placebo respectively Hoe 881 showed equal potency against hookworms and Acsaris as Pyrantel and good effectiveness against Trichuris. Pyrantel showed only moderate activity against Trichuris in this trial.
芬苯达唑（Hoe 881），即5-（苯硫基）-2-苯并咪唑氨基甲酸甲酯，每人服用1.0克和1.5克的剂量对蛔虫有效，且能大幅减少钩虫（主要是美洲板口线虫）的虫卵计数。1.5克的剂量对鞭虫效果良好。在一项使用比表面积为25平方米/克的Hoe 881悬浮液的试验中，与比表面积约为8平方米/克的片剂相比并无优势。间隔24小时服用两剂500毫克并不比一剂1.0克更有效。在一项对比试验中，分别使用1.5克的Hoe 881、10毫克/千克的噻嘧啶和安慰剂，结果显示Hoe 881对钩虫和蛔虫的效力与噻嘧啶相当，对鞭虫的效果良好。在该试验中，噻嘧啶对鞭虫仅表现出中等活性。
