Ueda J, Shimazu Y, Ozawa T
National Institute of Radiological Sciences, Chiba-shi, Japan.
Free Radic Biol Med. 1995 May;18(5):929-33. doi: 10.1016/0891-5849(94)00213-4.
Cu(II) complexes with oligopeptides containing histidyl residue in the second or third position could scarcely activate hydrogen peroxide (H2O2), but they could activate H2O2 to yield hydroxyl radical (.OH) in the presence of biological reductants such as cysteine and ascorbic acid. Further, DNA single strand breakage was also observed during the reactions of Cu(II)-glycylglycylhistidylglycine (GGHG) with H2O2 in the presence of same biological reductants.
在第二或第三位含有组氨酸残基的寡肽与铜（II）形成的配合物几乎不能激活过氧化氢（H2O2），但在半胱氨酸和抗坏血酸等生物还原剂存在的情况下，它们能够激活H2O2生成羟基自由基（·OH）。此外，在相同生物还原剂存在的情况下，当铜（II）-甘氨酰甘氨酰组氨酰甘氨酸（GGHG）与H2O2反应时，也观察到了DNA单链断裂。
