新型抗关节炎药物细胞分裂素对DBA/1J小鼠II型胶原诱导性关节炎和Lewis大鼠佐剂性关节炎的影响。

Effects of cytogenin, a novel anti-arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats.

作者信息

Hirano S, Wakazono K, Agata N, Mase T, Yamamoto R, Matsufuji M, Sakata N, Iguchi H, Tone H, Ishizuka M

机构信息

Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.

出版信息

Int J Tissue React. 1994;16(4):155-62.

PMID:7797401

Abstract

The anti-arthritic effects of cytogenin (8-hydroxy-3-hydroxymethyl-6- methoxyisocoumarin) on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats were examined. Prophylactic treatment with cytogenin (30, 100 mg/kg) had a potent inhibitory effect on type II collagen-induced arthritis. Prophylactic or therapeutic treatment with cytogenin (10, 30 and 100 mg/kg) also had a potent inhibitory effect on adjuvant arthritis. In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), cytogenin (10, 30 and 100 mg/kg) had neither an anti-inflammatory effect on carrageenan-induced paw oedema in rats nor an analgesic effect on acetic acid-induced writhing in mice. These results suggest that the mode of the anti-arthritic action of cytogenin is different from that of NSAIDs and that cytogenin may become a useful drug for the treatment of rheumatoid arthritis.

摘要

研究了细胞生成素（8-羟基-3-羟甲基-6-甲氧基异香豆素）对DBA/1J小鼠II型胶原诱导性关节炎和Lewis大鼠佐剂性关节炎的抗关节炎作用。用细胞生成素（30、100mg/kg）进行预防性治疗对II型胶原诱导性关节炎有显著抑制作用。用细胞生成素（10、30和100mg/kg）进行预防性或治疗性治疗对佐剂性关节炎也有显著抑制作用。与非甾体抗炎药（NSAIDs）不同，细胞生成素（10、30和100mg/kg）对大鼠角叉菜胶诱导的爪肿胀没有抗炎作用，对小鼠乙酸诱导的扭体也没有镇痛作用。这些结果表明，细胞生成素的抗关节炎作用模式与NSAIDs不同，细胞生成素可能成为治疗类风湿性关节炎的有用药物。