Yoon D Y, Kim S H, Kim H D, Na D G, Goo J M, Choi H J, Yeon K M, Han M C
Department of Radiology, Seoul National University College of Medicine, Korea.
Invest Radiol. 1995 Mar;30(3):168-72. doi: 10.1097/00004424-199503000-00006.
The purpose of this study is to investigate the temporal relation between the change in the resistive index (RI) from renal Doppler sonography and that of serum creatinine values in the course of experimentally induced reversible acute renal failure (ARF) in rabbits.
Reversible ARF was induced in 10 New Zealand white rabbits by injecting a glycerol solution (6.0 mL/kg) into the thigh muscle. Doppler sonography was performed before injection, and 6, 12, and 24 hours, and 3, 5, 7, and 14 days after injection of glycerol. Blood samples for measuring serum creatinine levels were obtained in the same time sequence. Three rabbits, which died during the course of the experiment, were excluded from the study group.
The RI elevated rapidly after glycerol injection, peaked at 12 hours, and then decreased to normal values by 7 days. Conversely, serum creatinine values were elevated and peaked at 1 day and then decreased to normal by 14 days. The change in the RI preceded the change in serum creatinine levels in the course of reversible ARF. There was a weak linear correlation between RI and serum creatinine levels, with a correlation coefficient of 0.33.
Doppler sonography with measurement of resistive index may be useful in predicting the course of ARF.
本研究旨在探讨家兔实验性诱导的可逆性急性肾衰竭（ARF）过程中，肾多普勒超声检查的阻力指数（RI）变化与血清肌酐值变化之间的时间关系。
通过向10只新西兰白兔大腿肌肉注射甘油溶液（6.0 mL/kg）诱导可逆性ARF。在注射前、注射甘油后6、12和24小时以及3、5、7和14天进行多普勒超声检查。按照相同的时间顺序采集用于测量血清肌酐水平的血样。实验过程中死亡的3只兔子被排除在研究组之外。
甘油注射后RI迅速升高，在12小时达到峰值，然后在7天内降至正常水平。相反，血清肌酐值在1天升高并达到峰值，然后在14天降至正常。在可逆性ARF过程中，RI的变化先于血清肌酐水平的变化。RI与血清肌酐水平之间存在弱线性相关性，相关系数为0.33。
测量阻力指数的多普勒超声检查可能有助于预测ARF的病程。
