Marinari U M, Pronzato M A, Dapino D, Gazzo P, Traverso N, Cottalasso D, Odetti P
Istituto di Patologia Generale, Università di Genova.
Ital J Biochem. 1995 Jan-Feb;44(1):1-9.
Increased levels of blood cholesterol are considered as a major factor in the development of atherosclerosis. Simvastatin, a drug which blocks hydroxymethylglutaryl coenzyme A reductase (HMGCoAR), reduces plasma cholesterol and increases HDL-cholesterol in rats fed a hypercholesterolemic diet. Moreover, simvastatin produces a significant decrease of ubiquinol and dolichol in plasma and in liver.
血液中胆固醇水平升高被认为是动脉粥样硬化发展的一个主要因素。辛伐他汀是一种能阻断羟甲基戊二酰辅酶A还原酶（HMGCoAR）的药物，在喂食高胆固醇饮食的大鼠中，它能降低血浆胆固醇并提高高密度脂蛋白胆固醇水平。此外，辛伐他汀能使血浆和肝脏中的泛醇和多萜醇显著减少。
