TAP1和TAP2二态性与多发性硬化易感性的关系。

The relationship of TAP1 and TAP2 dimorphisms to multiple sclerosis susceptibility.

作者信息

Bell R B, Ramachandran S

机构信息

Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Health Sciences Centre, Alberta, Canada.

出版信息

J Neuroimmunol. 1995 Jun;59(1-2):201-4. doi: 10.1016/0165-5728(95)00046-5.

DOI:10.1016/0165-5728(95)00046-5

PMID:7797617

Abstract

Transporters associated with antigen processing and presentation (TAP1 and TAP2) have been considered candidate genes in MS susceptibility based on evidence from experimental animal models confirming antigenic peptide selection by transporter polymorphisms and by the proximity of these transporter genes to the DR- and DQ-associated alleles known to confer disease risk in man. We report here an association study examining the influence of TAP gene polymorphisms on MS susceptibility in a Canadian patient population. Our results do not support a role for the five polymorphisms examined in the etiology of this disease.

摘要

基于实验动物模型的证据，与抗原加工和呈递相关的转运蛋白（TAP1和TAP2）被认为是多发性硬化易感性的候选基因，这些证据证实了转运蛋白多态性对抗原肽的选择作用，以及这些转运蛋白基因与已知会使人患疾病风险增加的DR和DQ相关等位基因的接近性。我们在此报告一项关联研究，该研究检测了TAP基因多态性对加拿大患者群体中多发性硬化易感性的影响。我们的结果不支持所检测的5种多态性在该疾病病因学中的作用。