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In vitro T cell function, delayed-type hypersensitivity skin testing, and CD4+ T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus.

作者信息

Dolan M J, Clerici M, Blatt S P, Hendrix C W, Melcher G P, Boswell R N, Freeman T M, Ward W, Hensley R, Shearer G M

机构信息

Department of Infectious Diseases, Wilford Hall Medical Center, Lackland Air Force Base, TX 78236-5300, USA.

出版信息

J Infect Dis. 1995 Jul;172(1):79-87. doi: 10.1093/infdis/172.1.79.

DOI:10.1093/infdis/172.1.79
PMID:7797948
Abstract

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P < .001) and time for progression to AIDS (P = .014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P < .001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P = .008), the absolute number of CD4+ T cells (P = .001), the percentage of CD4+ CD29+ cells (P = .06), and the number of reactive skin tests (P < .001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.

摘要

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