硫酸葡聚糖低密度脂蛋白分离去除术期间家族性高胆固醇血症患者甲状腺激素水平降低
Decrease of thyroid hormones in patients with familial hypercholesterolemia during dextran sulphate low-density lipoprotein apheresis.
作者信息
Pintus S, Pintus P, Piras C, Loviselli A, Muntoni S
机构信息
Dismetabolic Diseases Centre, St. Michele Hospital, Cagliari, Italy.
出版信息
J Clin Apher. 1994;9(2):124-5. doi: 10.1002/jca.2920090206.
PMID:7798159
Abstract
Removal of low-density lipoproteins from plasma by dextran sulfate adsorption (DSA) in FH patients entails a decrease in plasma levels of thyroid hormones (-28.5% and -18.7%, respectively, for T3 and T4). This suggests that FH patients have a greater than normal fraction of thyroid hormones bound to lipoproteins, due to their expanded lipoprotein pool.
摘要
通过硫酸葡聚糖吸附（DSA）从家族性高胆固醇血症（FH）患者血浆中去除低密度脂蛋白会导致甲状腺激素血浆水平降低（T3和T4分别降低28.5%和18.7%）。这表明，由于脂蛋白池扩大，FH患者与脂蛋白结合的甲状腺激素比例高于正常水平。
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