The Alzheimer's disease sphinx: a riddle with plaques and tangles.
作者信息
Kosik K S
机构信息
Department of Medicine (Division of Neurology), Brigham and Women's Hospital, Boston, Massachusetts 02115.
出版信息
J Cell Biol. 1994 Dec;127(6 Pt 1):1501-4. doi: 10.1083/jcb.127.6.1501.
Abstract
摘要
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Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease.淀粉样β肽与晚期糖基化终产物受体的相互作用引发巨噬细胞集落刺激因子的神经元表达：阿尔茨海默病中的一条促炎途径。
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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?引发淀粉样蛋白的“一维结晶”：阿尔茨海默病和羊瘙痒病的一种致病机制？
Cell. 1993 Jun 18;73(6):1055-8. doi: 10.1016/0092-8674(93)90635-4.
2
Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.通过大鼠海马切片的电去极化释放淀粉样β蛋白前体衍生物。
Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5191-3. doi: 10.1073/pnas.90.11.5191.
3
Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth.氨基酸序列RERMS代表促进成纤维细胞生长的β淀粉样蛋白/A4蛋白前体的活性结构域。
J Cell Biol. 1993 May;121(4):879-86. doi: 10.1083/jcb.121.4.879.
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Subcellular localization of tau mRNA in differentiating neuronal cell culture: implications for neuronal polarity.tau mRNA在分化的神经元细胞培养物中的亚细胞定位：对神经元极性的影响。
Neuron. 1993 Apr;10(4):627-38. doi: 10.1016/0896-6273(93)90165-n.
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Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.源自畸胎癌细胞系的人类神经元仅表达695个氨基酸的淀粉样前体蛋白，并产生细胞内β-淀粉样蛋白或A4肽。
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9513-7. doi: 10.1073/pnas.90.20.9513.
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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.蛋白质磷酸化抑制阿尔茨海默病淀粉样β/A4肽的产生。
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9195-8. doi: 10.1073/pnas.90.19.9195.
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Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.铝、铁和锌离子会促进生理浓度的β-淀粉样肽聚集。
J Neurochem. 1993 Sep;61(3):1171-4. doi: 10.1111/j.1471-4159.1993.tb03639.x.
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Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.载脂蛋白Eε4等位基因与晚发性家族性和散发性阿尔茨海默病的关联。
Neurology. 1993 Aug;43(8):1467-72. doi: 10.1212/wnl.43.8.1467.
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Intraneuronal compartments of the amyloid precursor protein.淀粉样前体蛋白的神经元内区室
J Neurosci. 1993 Jul;13(7):3112-23. doi: 10.1523/JNEUROSCI.13-07-03112.1993.
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