Krell J M, Sanchez R L, Solomon A R
Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322.
J Cutan Pathol. 1994 Aug;21(4):363-70. doi: 10.1111/j.1600-0560.1994.tb00713.x.
Reactive angioendotheliomatosis (RA) is a rare, benign disease. Affected patients present with self-limited, erythematous to violaceous plaques. The clinical lesions are due to intravascular hyperplasia of cytologically banal endothelial cells in the dermis. We report 2 patients who presented with ulcerated, violaceous plaques on the lower extremities. Both had severe peripheral vascular atherosclerotic disease requiring bypass grafts. Unlike previously described cases of RA, our patient's lesions were due to a diffuse proliferation of endothelial cells in the reticular dermis with only minimal, focal intravascular proliferation of these cells. Positive immunostaining with antibodies to Factor VIII-related and CD34 antigens adds evidence that the proliferated cells in the dermis were endothelial cells.
反应性血管内皮瘤病（RA）是一种罕见的良性疾病。患病患者表现为自限性的、从红斑到紫蓝色的斑块。临床损害是由于真皮内细胞学上普通的内皮细胞的血管内增生所致。我们报告2例患者，他们下肢出现了溃疡的紫蓝色斑块。两人都有严重的外周血管动脉粥样硬化疾病，需要进行搭桥手术。与先前描述的RA病例不同，我们患者的损害是由于网状真皮内内皮细胞的弥漫性增殖，而这些细胞仅在血管内有极少的局灶性增殖。用抗VIII因子相关抗原和CD34抗原的抗体进行免疫染色阳性，进一步证明真皮内增殖的细胞是内皮细胞。
