α-干扰素（INF-α）与依曲替酯治疗蕈样肉芽肿。

Interferon-alpha (INF-alpha) and etretinate in the treatment of mycosis fungoides.

作者信息

Torii H, Kaneko T, Matsuyama T, Nakanishi H, Harada S

机构信息

Department of Dermatology, Kanto Teishin Hospital, Japan.

出版信息

J Dermatol. 1994 Oct;21(10):767-70. doi: 10.1111/j.1346-8138.1994.tb03285.x.

DOI:10.1111/j.1346-8138.1994.tb03285.x

PMID:7798436

Abstract

A combination therapy of mycosis fungoides (MF) with interferon-alpha (INF-alpha) and etretinate was reported. A 53-year-old patient suffering from MF was treated with intramuscular administration of INF-alpha at a dosage of 9 x 10(6) IU daily; skin lesions poorly responded to the treatment. After oral etretinate with a dosage of 50 mg daily was combined with INF-alpha, marked clinical improvement was seen in skin lesions with minor side effects. INF-alpha in combination with etretinate can have beneficial effects in the treatment of MF.

摘要

有报道称采用干扰素-α（INF-α）和阿维A酯联合治疗蕈样肉芽肿（MF）。一名53岁的MF患者接受了每日9×10⁶国际单位的INF-α肌肉注射治疗；皮肤病变对该治疗反应不佳。在每日50毫克的阿维A酯口服与INF-α联合使用后，皮肤病变有明显的临床改善，且副作用较小。INF-α与阿维A酯联合使用对MF治疗可能有有益效果。