Wardlaw A J, Symon F S, Walsh G M
Department of Respiratory Medicine, Leicester University School of Medicine, Glenfield Hospital, UK.
J Allergy Clin Immunol. 1994 Dec;94(6 Pt 2):1163-71. doi: 10.1016/0091-6749(94)90327-1.
Eosinophil adhesion has been studied in some detail in recent years, and a number of interesting observations have emerged. As with other aspects of eosinophil biology, there appears to be a greater similarity with basophils than with neutrophils in their pattern of adhesion interactions. A number of important differences with respect to neutrophils have emerged, which could be exploited for the treatment of eosinophil-mediated disease, including the observations that eosinophil adhesion can be modulated by selective cytokines such as IL-5 and that eosinophils, unlike neutrophils, express VLA-4 and alpha 4/beta 7. There is also tantalizing evidence emerging that eosinophils interact differentially with the selectins, with differing degrees of affinity of binding and possibly different counterreceptors. The extent to which these observations will be useful in treating allergic disease remains to be seen.
近年来，嗜酸粒细胞黏附已得到较为详细的研究，并出现了一些有趣的观察结果。与嗜酸粒细胞生物学的其他方面一样，在黏附相互作用模式方面，嗜酸粒细胞与嗜碱性粒细胞的相似性似乎大于与中性粒细胞的相似性。已经出现了一些与中性粒细胞有关的重要差异，这些差异可用于治疗嗜酸粒细胞介导的疾病，包括嗜酸粒细胞黏附可被诸如白细胞介素-5等选择性细胞因子调节，以及嗜酸粒细胞与中性粒细胞不同，表达极迟抗原-4（VLA-4）和α4/β7等观察结果。也有引人关注的证据表明，嗜酸粒细胞与选择素的相互作用存在差异，具有不同程度的结合亲和力以及可能不同的反受体。这些观察结果在治疗过敏性疾病方面的有用程度还有待观察。
