Ageenko A I, Vitorgan Iu E, Gorozhanskaia E G, Shapot V S
Biull Eksp Biol Med. 1976 May;81(5):550-2.
A study was made of the activity of hexokinase in the soluble fraction of the nucleus and cytoplasm of fibroblasts of rat embryos (primary cultures) during contact with infectious (A6) and oncogenic (A12) human adenoviruses. A high activity of the enzyme was seen in the cytoplasmic fraction in comparison with the nuclear one both in the infectious adrenovirus of type 6 this value differed from the normal and in the experimental samples. With the action of the normal but insignificantly. Marked changes in the enzyme activity were observed in case of cell contact with the oncovirus. They occurred both in the nucleus and in the cytoplasm the first days of the virus inculcation, increasing gradually with the lapse of tiay; these disturbances were much greatert in the cytoplasm than in the nucleus. It is supposed that the changes revealed possibly associated with the impossibility to regulate the cell proliferation process.
对大鼠胚胎成纤维细胞（原代培养）的细胞核和细胞质可溶性部分中己糖激酶的活性进行了研究，该研究是在细胞与感染性（A6）和致癌性（A12）人腺病毒接触期间进行的。与细胞核部分相比，在细胞质部分观察到该酶具有较高的活性，这在6型感染性腺病毒以及实验样本中均如此，该值与正常情况不同，但差异不显著。在正常情况下作用不明显。当细胞与肿瘤病毒接触时，观察到酶活性发生显著变化。在接种病毒的最初几天，细胞核和细胞质中均出现这些变化，并随着时间的推移逐渐增加；这些干扰在细胞质中比在细胞核中更为明显。据推测，所揭示的这些变化可能与无法调节细胞增殖过程有关。
