Manatsathit S, Kachintorn U, Boonyapisit S, Loengrojanakul P, Tanwandee T, Chinapak O
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1993 Dec;76(12):677-82.
Acid secretion in both basal and stimulated states (using augmented histalog test) was studied in 31 normal control patients, 64 duodenal ulcer patients and 101 gastric ulcer patients. Having had the result of acid output study, the 64 DU patients could be classified according to their acid secretion results as 35 DU type I or Normosecretor (54.7%) and 29 DU type II or Hypersecretor (45.3%). For the GU patients which were classified according to the sites of lesions as GU type I (GU above angulus), GU type II (GU associated with DU) and GU type III (GU below the angulus). Their acid output study showed that the GU type I had a rather low BAO and a high MAO close to that of the Normosecretor, but the GU type II and III had their BAO and MAO significantly higher than that of the normal control and close to that of the Hypersecretor. Comparison of acid secretion in this study group to other racial groups showed that the Thai population had acid secretion patterns close to other Asian populations, except that the Chinese in Singapore had a higher proportion of Normosecretor (69.0%) than Hypersecretor (31%). The MAO of the Asian population was found to be lower than that of Europeans.
对31名正常对照患者、64名十二指肠溃疡患者和101名胃溃疡患者进行了基础状态和刺激状态（采用加大剂量组胺试验）下的胃酸分泌研究。根据胃酸分泌研究结果，64名十二指肠溃疡患者可根据其胃酸分泌结果分为35名I型十二指肠溃疡患者或正常分泌者（54.7%）和29名II型十二指肠溃疡患者或高分泌者（45.3%）。对于胃溃疡患者，根据病变部位分为I型胃溃疡（胃角以上的胃溃疡）、II型胃溃疡（与十二指肠溃疡相关的胃溃疡）和III型胃溃疡（胃角以下的胃溃疡）。他们的胃酸分泌研究表明，I型胃溃疡患者基础胃酸分泌量相当低，最大胃酸分泌量接近正常分泌者，但II型和III型胃溃疡患者的基础胃酸分泌量和最大胃酸分泌量显著高于正常对照组，接近高分泌者。将该研究组的胃酸分泌情况与其他种族群体进行比较，结果显示，泰国人群的胃酸分泌模式与其他亚洲人群相近，只是新加坡华人中正常分泌者（69.0%）的比例高于高分泌者（31%）。发现亚洲人群的最大胃酸分泌量低于欧洲人群。
