Engler-Pinto Júnior P, Gama-Rodrigues J, Lopasso F P, Cordeiro A C, Saez-Alquezar A, Laudanna A A, Pinotti H W
Department of Gastroenterology, Sao Paulo Faculty of Medicine, Brazil.
Hepatogastroenterology. 1996 Nov-Dec;43(12):1671-7.
BACKGROUND/AIMS: Basal (BAO) and maximum (PAO) hydrochloric acid output after Histalog stimulation, basal pepsinogen (SPL-B), at 60 (SPL-60) and at 90 minutes (SPL-90), and basal gastrin (BG) levels were measured and compared in different gastric (GU) and duodenal (DU) ulcer sites.
Fifty nine patients with peptic ulcer were grouped according to Johnson's classification for gastric ulcers: type I (15), type II (16) type III (12) GU and (16) DU. Fifteen normal subjects were studied as controls.
The BAO was greater in the DU than in the control or GU groups. No significant difference was noted in the production of hydrochloric acid after stimulation with Histalog. The SPL-B, at 60 and at 90 minutes was higher in type II GU than in the DU group and controls. The SPL-60 was higher in type II GU patients than in type III GU. Basal gastrin was higher in group DU and types II and III GU compared to the type I GU patients and controls.
The topographic criteria for differentiating peptic ulcers has low discrimination capacity based on comparison of mean values of HCl acid production, pepsinogen and gastrin serum levels both basal and after stimulation with Histalog due to heterogeneity of these variables in group studies. In these studies, peptic ulcers from different sites should not be grouped as distinct entities except for type II gastric ulcers.
背景/目的：测量并比较不同胃溃疡（GU）和十二指肠溃疡（DU）部位在组胺刺激后的基础盐酸分泌量（BAO）和最大盐酸分泌量（PAO）、基础胃蛋白酶原（SPL - B）、60分钟时（SPL - 60）和90分钟时（SPL - 90）的胃蛋白酶原以及基础胃泌素（BG）水平。
59例消化性溃疡患者根据约翰逊胃溃疡分类法分组：I型（15例）、II型（16例）、III型（12例）胃溃疡以及（16例）十二指肠溃疡。15名正常受试者作为对照进行研究。
十二指肠溃疡组的基础盐酸分泌量高于对照组和胃溃疡组。组胺刺激后盐酸分泌量无显著差异。II型胃溃疡患者60分钟和90分钟时的基础胃蛋白酶原水平高于十二指肠溃疡组和对照组。II型胃溃疡患者的60分钟基础胃蛋白酶原水平高于III型胃溃疡患者。与I型胃溃疡患者及对照组相比，十二指肠溃疡组以及II型和III型胃溃疡患者的基础胃泌素水平更高。
由于在分组研究中这些变量存在异质性，基于基础及组胺刺激后盐酸分泌量、胃蛋白酶原和胃泌素血清水平的平均值比较，用于区分消化性溃疡的地形学标准的鉴别能力较低。在这些研究中，除II型胃溃疡外，不同部位的消化性溃疡不应被归为不同的实体。
