Chusil S, Tungsanga K, Wathanavaha A, Pansin P
Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
J Med Assoc Thai. 1994 Feb;77(2):98-102.
A Thai female patient developed muscular weakness, hypouricemia, hypokalemia and hyperchloremic metabolic acidosis after taking outdated tetracycline. A pathophysiologic study shows a proximal tubular defect for reabsorption of urate and bicarbonate and a distal tubular acidification defect, probably caused by outdated tetracycline.
一名泰国女性患者在服用过期四环素后出现肌肉无力、低尿酸血症、低钾血症和高氯性代谢性酸中毒。一项病理生理学研究表明，可能是过期四环素导致近端肾小管对尿酸盐和碳酸氢盐的重吸收出现缺陷，以及远端肾小管酸化功能障碍。
