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运用DNA-DNA原位杂交技术检测癌前及恶性宫颈病变中的多种人乳头瘤病毒类型。

Detection of various types of human papillomaviruses in premalignant and malignant cervical lesions using DNA-DNA in situ hybridization.

作者信息

Nimmanahaeminda K, Thamprasert K, Chantratita W

机构信息

Department of Pathology, Faculty of Medicine, Faculty of Medical Technology, Chiang Mai University, Thailand.

出版信息

J Med Assoc Thai. 1994 Mar;77(3):120-5.

PMID:7798845
Abstract

Detection of human papillomavirus (HPV) in formalin-fixed paraffin embedded tissue sections by in situ hybridization technique employing biotinylated (HPV) DNA probe 6/11, 16/18 and 31/33/35 was done retrospectively in 25 cases of cervical dysplasia, 32 cases of cervical squamous cell carcinoma in situ, 52 cases of invasive cervical squamous cell carcinoma and 7 cases of adenocarcinoma. HPV could be demonstrated in 10 cases (40.00%) of cervical dysplasia, 8 cases (25.00%) of cervical squamous cell carcinoma in situ and 31 cases (59.61%) of invasive cervical squamous cell carcinoma and 4 cases (57.14%) of adenocarcinoma. Among the dysplastic cases, 4 cases showed HPV 31/33/35, 4 cases showed HPV 16/18 together with HPV 31/33/35, 1 case showed mixed typing of HPV 6/11 and 31/33/35, and 1 case showed mixed typing of HPV 6/11, 16/18 and 31/33/35. In 32 cases of squamous cell carcinoma in situ, 1 case of HPV 6/11; 3 cases of HPV 16/18, 3 cases of HPV 31/33/35 and 1 case of mixed typing of HPV 16/18 and 31/33/35 were present. A case of HPV 6/11, 10 cases of HPV 16/18 and 9 cases of HPV 31/33/35 could be detected among the cases of invasive squamous cell carcinoma. Mixed typing of HPV 6/11 and 16/18; HPV 6/11 and 31/33/35; HPV 16/18 and 31/33/35; HPV 6/11, 16/18 and 31/33/35 were revealed in 2, 1, 3 and 5 cases of invasive squamous cell carcinoma, respectively. In 7 cases of adenocarcinoma, 1, 2 and 1 cases exhibited positivity for HPV 16/18; HPV 6/11 and HPV 16/18; and HPV 16/18 and HPV 31/33/35.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

采用生物素化的人乳头瘤病毒（HPV）DNA探针6/11、16/18和31/33/35，通过原位杂交技术对25例宫颈发育异常、32例宫颈原位鳞状细胞癌、52例浸润性宫颈鳞状细胞癌和7例腺癌的福尔马林固定石蜡包埋组织切片进行人乳头瘤病毒检测。结果显示，在25例宫颈发育异常病例中，10例（40.00%）检测到HPV；32例宫颈原位鳞状细胞癌病例中，8例（25.00%）检测到HPV；52例浸润性宫颈鳞状细胞癌病例中，31例（59.61%）检测到HPV；7例腺癌病例中，4例（57.14%）检测到HPV。在发育异常病例中，4例显示HPV 31/33/35，4例显示HPV 16/18与HPV 31/33/35共存，1例显示HPV 6/11和31/33/35混合分型，1例显示HPV 6/11、16/

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