Inhalation sedation with sevoflurane: a comparative study with nitrous oxide.

作者信息

Haraguchi N, Furusawa H, Takezaki R, Oi K

机构信息

1st Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.

出版信息

J Oral Maxillofac Surg. 1995 Jan;53(1):24-6; discussion 26-7. doi: 10.1016/0278-2391(95)90493-x.

PURPOSE

To evaluate the possibility of using sevoflurane for inhalation sedation.

PATIENTS AND METHODS

Thirty-five volunteers were divided randomly into two groups: sevoflurane group (n = 20) and nitrous oxide (N2O) group (n = 15). At the beginning of the sedation they all inhaled 100% O2, then a 0.1 minimum alveolar concentration (MAC) of sevoflurane or 10% N2O with oxygen, a 0.2 MAC of sevoflurane or 20% N2O with oxygen, and 0.3 MAC of sevoflurane or 30% N2O with oxygen for 10 minutes each.

RESULTS

The respiratory and cardiovascular functions were stable during inhalation of the gas mixtures. There were five negative comments about breathing N2O, but none about breathing sevoflurane.

CONCLUSION

All subjects in the sevoflurane group stated they would be willing to submit to the same inhalation procedure again.