骨髓增生异常和骨髓增殖性疾病患者的风湿性表现。
Rheumatic manifestations in patients with myelodysplastic and myeloproliferative diseases.
作者信息
Kuzmich P V, Ecker G A, Karsh J
机构信息
Division of Rheumatology, Ottawa General Hospital, University of Ottawa, ON, Canada.
出版信息
J Rheumatol. 1994 Sep;21(9):1649-54.
OBJECTIVE
To evaluate the rheumatic complications in patients with myelodysplastic and myeloproliferative diseases.
METHODS
A retrospective chart review of patients with a rheumatic disease and either a myelodysplastic or myeloproliferative disorder diagnosed on bone marrow examination.
RESULTS
Nine patients were identified, 5 with myelodysplastic and 4 with myeloproliferative disorders. Polyarthritis was the most common rheumatic presentation, occurring in 6 patients with a positive rheumatoid factor in 4. Necrotizing vasculitis complicated the course in 3 patients. Autoantibodies and hypergammaglobulinemia were present in the majority of patients.
CONCLUSION
There is an association between hematologic disorders caused by proliferation of bone marrow derived pluripotent stem cells and rheumatic disorders.
目的
评估骨髓增生异常和骨髓增殖性疾病患者的风湿性并发症。
方法
对经骨髓检查诊断为患有风湿性疾病以及骨髓增生异常或骨髓增殖性疾病的患者进行回顾性病历审查。
结果
共确定9例患者，其中5例为骨髓增生异常疾病，4例为骨髓增殖性疾病。多关节炎是最常见的风湿性表现，6例患者出现该症状，其中4例类风湿因子呈阳性。3例患者病程中并发坏死性血管炎。大多数患者存在自身抗体和高球蛋白血症。
结论
骨髓源性多能干细胞增殖引起的血液系统疾病与风湿性疾病之间存在关联。
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