Abbas Z, Qureshi A A, Sheikh H, Jafri S M, Khan A H
Department of Medicine and Pathology, Aga Khan University Medical Centre, Karachi.
J Pak Med Assoc. 1994 Sep;44(9):206-9.
Histological changes in 20 Giardia positive duodenal biopsies (Group A) were compared with 50, Giardia negative duodenal biopsies (Group B), taken during the same period. Stool examinations in Group B were negative for Giardia. Surface epithelium, villous and crypt architecture and cellular infiltrates were examined and compared between the groups. Atrophic changes in the villi were more common in Group A as compared to B(P < 0.0001). Intraepithelial neutrophil infiltration (P < 0.001), infiltration of the lamina propria with plasma cells (P < 0.5), and presence of eosinophils in the lamina propria (P < 0.001) were significant findings in group A. Some of the changes were related to the density of Giardia colonization e.g., the goblet cell depletion (P < 0.05) and the density of plasma cell infiltration in lamina propria (P < 0.01). Erosions and ulcerations were less commonly seen in group A. Thus we conclude that giardiasis manifests its peculiar features in the distal duodenal mucosa and a biopsy of this region is an important diagnostic tool for detection of this disease.
将20份贾第虫阳性十二指肠活检样本（A组）的组织学变化与同期采集的50份贾第虫阴性十二指肠活检样本（B组）进行比较。B组的粪便检查贾第虫呈阴性。对两组的表面上皮、绒毛和隐窝结构以及细胞浸润情况进行检查和比较。与B组相比，A组绒毛萎缩性变化更为常见（P < 0.0001）。A组上皮内中性粒细胞浸润（P < 0.001）、固有层浆细胞浸润（P < 0.5）以及固有层嗜酸性粒细胞的存在（P < 0.001）均为显著发现。部分变化与贾第虫定植密度有关，例如杯状细胞减少（P < 0.05）和固有层浆细胞浸润密度（P < 0.01）。A组糜烂和溃疡较少见。因此我们得出结论，贾第虫病在十二指肠远端黏膜表现出其独特特征，该区域的活检是检测该病的重要诊断工具。
