Oberhuber G, Stolte M
Department of Pathology, University of Innsbruck, Austria.
J Clin Pathol. 1990 Aug;43(8):641-3. doi: 10.1136/jcp.43.8.641.
Histological changes in duodenal biopsy specimens from 80 patients infected with Giardia lamblia were defined and compared with changes in duodenal biopsy specimens from 80 randomly chosen "healthy" patients. Villous architecture, the number of intraepithelial lymphocytes, the occurrence of lymphoid follicles and the density of colonisation by G lamblia trophozoites were examined. Grade 1 villous flattening was observed in 41% of cases positive for Giardia and in 37.5% of the control cases. The mean content of intraepithelial lymphocytes was 24.5 compared with 22.6 intraepithelial lymphocytes/100 epithelial cells in the positive and negative groups, respectively. Lymphoid follicles were more frequently observed in Giardia positive specimens, but their incidence was not significantly higher compared with that of controls. Twenty five per cent of patients positive for Giardia showed light, 41% intermediate, and 34% heavy colonisation by Giardia trophozoites. In 76% the parasites were observed in all specimens obtained. It is concluded that histological changes induced by G lamblia are not specific, and that two duodenal biopsy specimens might suffice to detect the trophozoites.
对80例感染蓝氏贾第鞭毛虫患者的十二指肠活检标本的组织学变化进行了界定，并与80例随机选取的“健康”患者的十二指肠活检标本变化进行了比较。检查了绒毛结构、上皮内淋巴细胞数量、淋巴滤泡的出现情况以及蓝氏贾第鞭毛虫滋养体的定植密度。在41%的贾第鞭毛虫阳性病例和37.5%的对照病例中观察到1级绒毛扁平。上皮内淋巴细胞的平均含量为24.5，而阳性组和阴性组上皮内淋巴细胞分别为22.6/100个上皮细胞。在贾第鞭毛虫阳性标本中更频繁地观察到淋巴滤泡，但其发生率与对照组相比无显著升高。25%的贾第鞭毛虫阳性患者显示轻度、41%为中度、34%为重度贾第鞭毛虫滋养体定植。在76%的病例中，在所有获取的标本中均观察到寄生虫。结论是，蓝氏贾第鞭毛虫引起的组织学变化不具有特异性，两份十二指肠活检标本可能足以检测到滋养体。
