Gerald M C, Richter N A
Psychopharmacologia. 1976 Apr 15;46(3):277-82. doi: 10.1007/BF00421114.
The influence of pharmacological modifications of the functional activity of the central histaminergic system was studied on the susceptibility of mice to pentylenetetrazol-induced minimal (clonic) and maximal (tonic) seizures. Enhancement in the functional activity of the system by central administration of histamine or 4-methylhistamine of peripheral L-histidine loading failed to modify the risk of seizures. By contrast, reduction in histaminergic function was found to alter seizure susceptibility. Brocresine, an inhibitor of histamine synthesis, decreased and increased the risk of pentylenetetrazol-induced minimal and maximal seizures, respectively. Many, but not all, classical anti-histamines (H1 antagonist) and metiamide (H2 antagonist) and metiamide (H2 antagonist) increased minimal seizure susceptibility after periheral and intraventricular administration, respectively.
研究了中枢组胺能系统功能活性的药理学改变对小鼠对戊四氮诱导的最小（阵挛性）和最大（强直性）惊厥易感性的影响。通过中枢给予组胺或外周L-组氨酸负荷的4-甲基组胺来增强该系统的功能活性，未能改变惊厥风险。相比之下，发现组胺能功能降低会改变惊厥易感性。组胺合成抑制剂溴克辛分别降低和增加了戊四氮诱导的最小和最大惊厥的风险。许多（但不是全部）经典抗组胺药（H1拮抗剂）和甲硫咪特（H2拮抗剂）分别在经外周和脑室内给药后增加了最小惊厥易感性。
