Vasey F B, Havice D L, Bocanegra T S, Seleznick M J, Bridgeford P H, Martinez-Osuna P, Espinoza L R
Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612-4799.
Semin Arthritis Rheum. 1994 Aug;24(1 Suppl 1):22-8. doi: 10.1016/0049-0172(94)90106-6.
We report the clinical findings in a series of women with silicone breast implants (SBI) and rheumatic disease. These findings represent the first 50 patients seen at the University of South Florida Medical Clinic between March 1977 and January 1991. The average age was 44 years with a range of 30 to 66 years. The most common clinical findings included chronic fatigue, muscle pain, joint pain, joint swelling, and lymphadenopathy. Seventeen women with an average Steinbrocker functional class of 1.8 decided not to remove the implants. An average of 14 months later, follow-up showed no change in their condition. Thirty-three women, with an average functional class of 2.5 underwent implant removal. Twelve of the 33 had documented implant rupture. During an average follow-up of 22 months after implant removal, 24 women improved clinically, 8 did not change, and 1 worsened. We believe this series supports a relationship between silicone breast implants and rheumatic disease signs and symptoms. Although this report is not a definitive epidemiological study, findings suggest that physicians should inform women about the possible benefit of implant removal.
我们报告了一系列接受硅胶乳房植入物（SBI）且患有风湿性疾病的女性的临床研究结果。这些结果涵盖了1977年3月至1991年1月期间在南佛罗里达大学医学诊所就诊的首批50名患者。患者平均年龄为44岁，年龄范围在30至66岁之间。最常见的临床症状包括慢性疲劳、肌肉疼痛、关节疼痛、关节肿胀和淋巴结病。17名平均Steinbrocker功能分级为1.8的女性决定不取出植入物。平均14个月后随访发现她们的病情没有变化。33名平均功能分级为2.5的女性接受了植入物取出手术。33名患者中有12名记录显示植入物破裂。在植入物取出后平均22个月的随访期间，24名女性临床症状改善，8名无变化，1名病情恶化。我们认为这一系列研究结果支持硅胶乳房植入物与风湿性疾病体征和症状之间存在关联。尽管本报告并非确定性的流行病学研究，但研究结果表明医生应告知女性取出植入物可能带来的益处。
