Lindholm J, Korsgaard O, Rasmussen P, Micic S
Eur J Clin Invest. 1976 Jun 21;6(3):249-54. doi: 10.1111/j.1365-2362.1976.tb00517.x.
Serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) before and after intravenous injection of luteinizing hormone releasing hormone (LHRH) were studied in 71 male and female subjects of various ages. Mean basal FSH and LH levels were not significantly different in the male groups, except that FSH was significantly higher in the very old subjects. Postmenopausal female subjects had much higher concentrations of both hormones than had premenopausal women. LH was higher in female subjects shortly after the menopause than in very old female subjects. The serum concentrations of both FSH and LH 30 min. after intravenous injection of 200 mug LHRH were not different from the 60 min. values. There was no significant difference in the response of LH in the male groups. The peak FSH concentration was higher in the very old male subjects. Postmenopausal women had a much higher peak concentration of both FSH and LH than had younger subjects. The increment of LH, but not of FSH, was larger in female subjects shortly after the menopause than in very old female subjects. In both sexes there was a significant correlation between the basal FSH/LH ratio and age. In younger male subjects there was a close positive correlation between basal LH and serum testosterone, in older male subjects this correlation was negative and significant.
在71名不同年龄段的男性和女性受试者中，研究了静脉注射促黄体生成素释放激素（LHRH）前后的血清促卵泡激素（FSH）和促黄体生成素（LH）水平。男性组的平均基础FSH和LH水平无显著差异，但高龄受试者的FSH显著更高。绝经后女性受试者的这两种激素浓度均远高于绝经前女性。绝经后不久的女性受试者的LH高于高龄女性受试者。静脉注射200微克LHRH后30分钟时的FSH和LH血清浓度与60分钟时的值无差异。男性组中LH的反应无显著差异。高龄男性受试者的FSH峰值浓度更高。绝经后女性的FSH和LH峰值浓度均远高于年轻受试者。绝经后不久的女性受试者中LH的增加值大于高龄女性受试者，但FSH的增加值并非如此。在两性中，基础FSH/LH比值与年龄之间均存在显著相关性。在年轻男性受试者中，基础LH与血清睾酮之间存在密切的正相关，而在老年男性受试者中，这种相关性为负且显著。
