Tombolini V, Banelli E, Zotti P, Osti M, Zurlo A, Guidi C, Enrici R M
Divisione di Radioterapia Oncologica, Università degli Studi di Roma La Sapienza, Roma.
Minerva Urol Nefrol. 1994 Sep;46(3):163-6.
The authors analyse the results of treatment with radiotherapy with therapeutic doses and traditional fractionation scheme 60 patients affected by bladder cancer, from 1980 through 1991, at the Institute of Radiology of the University "La Sapienza" in Rome. We evaluated the association of radiotherapy (RT) with trans-urethral resection and biopsy (TURB) and the association of RT with cystectomy (total or partial), both in T1-T2 and T3-T4 bladder stages. The mean follow-up was 85 months (from 24 months to 11 years). The survival at 5 years after completing the treatment was 33.3%; the survival of stages T1-T2 was of 40% at 5 years while that of stages T3-T4 was of 28.5%. Our study shows that the association of radiotherapy and TURB for T1 or T2 bladder cancer is an alternative to mutilating surgery like total or partial cystectomy; in this group, indeed, we showed a survival of 54.5% at 5 years as compared to the 28.5% of the group treated with cystectomy + RT. For T3 and T4 bladder cancer we had better results with surgery (total or partial cystectomy) and RT: in these patients the survival at 5 years was of 31%, while the group treated with TURB + RT showed a survival of 19%.
作者分析了1980年至1991年期间，在罗马“La Sapienza”大学放射研究所，采用治疗剂量和传统分割方案对60例膀胱癌患者进行放射治疗的结果。我们评估了放射治疗（RT）与经尿道切除术和活检（TURB）的联合应用，以及RT与膀胱切除术（全膀胱或部分膀胱切除术）在T1 - T2期和T3 - T4期膀胱癌中的联合应用。平均随访时间为85个月（从24个月到11年）。治疗完成后5年生存率为33.3%；T1 - T2期5年生存率为40%，而T3 - T4期为28.5%。我们的研究表明，对于T1或T2期膀胱癌，放射治疗与TURB联合应用是全膀胱或部分膀胱切除术等致残性手术的替代方案；在这组患者中，实际上我们显示5年生存率为54.5%，而膀胱切除术 + RT治疗组的生存率为28.5%。对于T3和T4期膀胱癌，手术（全膀胱或部分膀胱切除术）和RT的效果更好：这些患者5年生存率为31%，而TURB + RT治疗组的生存率为19%。
