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尝试通过在体内用二甲基三氮烯咪唑甲酰胺处理来改变正常组织的抗原结构。

Attempt to alter antigenic structure of normal tissues by treatment with dimethyl-triazeno-imidazole-carboxamide in vivo.

作者信息

Nicolin A, Fagnani R, Nicolotti G, Goldin A

出版信息

Experientia. 1976 Jun 15;32(6):741-2. doi: 10.1007/BF01919863.

Abstract

The antigenic structure of normal skin and spleen cells has been investigated following in vivo treatment with the compound DIC. In experiments involving skin grafting in the normal and sensitized host, cross sensitization with a DIC-antigenic lymphoma and 3H-thymidine incorporation by lymphocytes cultured with DIC-treated spleen cells, new antigens on DIC-treated tissues were not demonstrated.

摘要

在用化合物DIC进行体内治疗后,对正常皮肤和脾细胞的抗原结构进行了研究。在涉及正常和致敏宿主皮肤移植、与DIC抗原性淋巴瘤交叉致敏以及用DIC处理的脾细胞培养的淋巴细胞掺入3H-胸腺嘧啶核苷的实验中,未证实DIC处理组织上有新抗原。

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