Windolf J, Oremek G, Inglis R, Zega A
Unfallchirurgische Klinik, Johann-Wolfgang-Goethe-Universität Frankfurt am Main.
Unfallchirurgie. 1994 Oct;20(5):239-50. doi: 10.1007/BF02588702.
The study presented investigates prospectively the clinical value of the PMN-elastase as a sequel parameter in 954 patients of a surgical intensive care unit. The elastase-values measured discriminate highly significant between patients with and without complications (p < 0.001) as well as between survivors and non-survivors (p < 0.001). Furthermore in patients underlying shock-phases in the course of treatment significantly higher elastase values are measured as in the patients remaining (p < 0.001). The highest prognostic evidence is determined by the elastase at the 9th day of course of disease concerning the prediction of a patient's death (sensitivity 78%, specificity 75%, positive predictive value 63%, respectively negative predictive value 87%).
本研究前瞻性地调查了在954例外科重症监护病房患者中，中性粒细胞弹性蛋白酶作为后续参数的临床价值。所测弹性蛋白酶值在有并发症和无并发症患者之间（p < 0.001）以及幸存者和非幸存者之间（p < 0.001）有高度显著差异。此外，在治疗过程中处于休克阶段的患者所测弹性蛋白酶值明显高于其余患者（p < 0.001）。在病程第9天，弹性蛋白酶对于预测患者死亡具有最高的预后证据（敏感性分别为78%、特异性为75%、阳性预测值为63%、阴性预测值为87%）。
