Rozenberg O A, Loshakova L V, Mikhaĭlova N Ia, Tiutin L A, Ternovoĭ S K, Balashov A T, Khanson K P
Vestn Rentgenol Radiol. 1993 Sep-Oct(5):35-8.
Clinical trials of the liposomal form of water-soluble x-ray contrast agent triombrast (90 mg of iodine in 1 ml) was carried out in 23 patients with Hodgkin's disease, 9 with liver cirrhosis, and 6 with malignant tumors of different localizations. Distinct images of the liver and spleen appeared 2-2.5 h after intravenous injection of the formulation. They could be observed during 4-6 h by plane radiography. Liposomal hepatolienography permits identification of the structural alteration sites 0.8-1.0 cm in size in these organs. Administration of higher doses of the formulation (more that 0.5 ml/kg) was associated with such side effects as fever and hyperthermia in 30% of patients parallel with the side effects common for iodine-containing x-ray contrast agents. These side effects could be eliminated by previous administration of prednisolone and pipolphen. These side effects were not observed after injection of lower doses of the formulation (less than 0.5 ml/kg) sufficient for an essential improvement of the image contrast during computer-aided tomography.
对脂质体形式的水溶性X射线造影剂碘海醇（每1毫升含90毫克碘）进行了临床试验，受试对象包括23例霍奇金病患者、9例肝硬化患者和6例不同部位恶性肿瘤患者。静脉注射该制剂后2至2.5小时，肝脏和脾脏的清晰图像显现出来。通过平面X线摄影可在4至6小时内观察到这些图像。脂质体肝脾造影术能够识别这些器官中大小为0.8至1.0厘米的结构改变部位。给予较高剂量的该制剂（超过0.5毫升/千克）时，30%的患者出现发热和体温过高的副作用，同时伴有含碘X射线造影剂常见的副作用。预先给予泼尼松龙和异丙嗪可消除这些副作用。注射较低剂量（低于0.5毫升/千克）的该制剂后未观察到这些副作用，此剂量足以在计算机断层扫描期间显著改善图像对比度。
