Payne N I, Whitehouse G H
Br J Radiol. 1987 Jun;60(714):535-41. doi: 10.1259/0007-1285-60-714-535.
Numerous methods for delineating the splenic pulp, including dynamic computed tomography scanning, either are unreliable or have other shortcomings. A method is described for enhancing the spleen using aqueous contrast media in conjunction with proliposomes. While liposomal carrier systems have previously been used for diagnostic purposes, proliposomes circumvent many of the problems associated with the manufacture and handling of liposomes. This enhancement is based on the selective uptake of particulate material by the reticuloendothelial system. While others, by using washed liposomal suspensions, have apparently obtained higher degrees of splenic contrast enhancement, the present study nevertheless shows that significant levels of enhancement are obtainable by a combination of intra- and extraliposomal contrast media.
用于描绘脾髓的方法众多，包括动态计算机断层扫描，但这些方法要么不可靠，要么存在其他缺点。本文描述了一种使用水性造影剂结合前体脂质体来增强脾脏显影的方法。虽然脂质体载体系统此前已用于诊断目的，但前体脂质体规避了许多与脂质体制造和处理相关的问题。这种增强作用基于网状内皮系统对颗粒物质的选择性摄取。虽然其他人通过使用洗涤过的脂质体悬浮液显然获得了更高程度的脾脏造影增强效果，但本研究仍表明，通过脂质体内外造影剂的联合使用可获得显著的增强水平。
