[Comparison of the tolerance of ionic and nonionic contrast media in coronary angiography].

To evaluate the tolerance of ionic versus nonionic CM, a double-blind randomized study was performed in 90 pts undergoing cardiac angiography. Nonionic CM caused fewer adverse reactions. These were no different in tolerance of two nonionic CM. Selective injections of urografin induced significant prolongation of RR, QT, PQ intervals on standard ECG of A-H and H-V intervals on intracardiac ECG. Nonionic CM induced the minimal electrophysiological disturbances. During left ventriculography urografin induced a significant decreased in left ventricular systolic pressure, -dp/dt value and increase in both end-diastolic pressure and heart rate. Nonionic CM produced less hemodynamics adverse effects. Urografin administration produced insignificant increasing of creatinine and urea blood levels. Minimal hemodynamics and ECG alterations caused by nonionic CM and low risk of complications determine the preferable using of nonionic CM in cardiac angiography.