Nakamura H, Kurata M, Haruta K, Takeda K
Toxicology Research Laboratories, Chugai Pharmaceutical Co., Ltd., Nagano, Japan.
J Vet Med Sci. 1994 Feb;56(1):91-6. doi: 10.1292/jvms.56.91.
Cardiovascular responses and radiographic image quality during cerebral angiography, aortofemoral angiography and left ventriculography with nonionic ioxilan, iohexol or iopamidol were compared with those of ionic sodium meglumine diatrizoate in pentobarbital anesthetized dogs. Injection of all contrast media caused cardiovascular changes to a greater or lesser degree, e.g., hypotension, bradycardia, tachycardia, a decrease in left ventricular pressure (LVP) and its first derivative (dP/dt), and prolongation of the P-Q and Q-T intervals. Ionic diatrizoate had a greater effect on cardiovascular parameters than nonionic contrast media during angiography in all areas. Moreover, diatrizoate produced cardiac arrhythmias and prominent changes in blood rheology concerned with blood viscosity and deformability of the erythrocyte. The cause of various effects of contrast media seemed to lie mainly in osmolality, viscosity and partially ionic additives. The radiographic image quality of all of the contrast media used was similar, but nonionic ioxilan and iohexol with lower iodine content and low osmolality gave better radio opacity than ionic diatrizoate in cerebral angiography. These results suggested that nonionic contrast media should be recommended as a diagnostic tool for both animals and human patients in poor health.
在戊巴比妥麻醉的犬中，比较了使用非离子型碘克沙醇、碘海醇或碘帕醇进行脑血管造影、主动脉股动脉造影和左心室造影期间的心血管反应及放射影像质量，与使用离子型泛影葡胺钠的情况进行对比。注射所有造影剂均或多或少引起心血管变化，例如低血压、心动过缓、心动过速、左心室压力（LVP）及其一阶导数（dP/dt）降低，以及P-Q和Q-T间期延长。在所有区域的血管造影过程中，离子型泛影葡胺对心血管参数的影响均大于非离子型造影剂。此外，泛影葡胺会引发心律失常，并导致与血液粘度和红细胞变形能力相关的血液流变学显著变化。造影剂产生各种效应的原因似乎主要在于渗透压、粘度以及部分离子添加剂。所使用的所有造影剂的放射影像质量相似，但在脑血管造影中，碘含量较低且渗透压较低的非离子型碘克沙醇和碘海醇比离子型泛影葡胺具有更好的放射不透明度。这些结果表明，对于健康状况不佳的动物和人类患者，应推荐使用非离子型造影剂作为诊断工具。
