Zawilska J B
Department of Pharmacodynamics, Medical University of Lódź, Poland.
Acta Neurobiol Exp (Wars). 1994;54 Suppl:47-56.
The vertebrate retina rhythmically synthesizes melatonin, a hormone involved in the regulation of several intraocular processes cued by environmental lighting conditions. The rhythm of retinal melatonin production, with maximal synthesis at night in darkness, is driven by the photoperiodic environment to which animals are exposed, and is generated by an endogenous circadian clock(s). This article reviews data on the role of dopamine, an established retinal neurotransmitter and paracrine factor, as a mediator of acute suppressive and entrainment action of light on the melatonin generating system in the retina. Special emphasis is given to the characterization of dopamine receptor types involved in the control of retinal melatonin formation.
脊椎动物的视网膜有节奏地合成褪黑素，这是一种参与调节多种眼内生理过程的激素，这些过程由环境光照条件所引发。视网膜褪黑素的合成节律，即在黑暗中的夜间合成量最大，是由动物所处的光周期环境驱动的，并由一个内源性生物钟产生。本文综述了多巴胺（一种已确定的视网膜神经递质和旁分泌因子）作为光对视网膜褪黑素生成系统的急性抑制和同步作用的介质的相关数据。特别强调了参与控制视网膜褪黑素形成的多巴胺受体类型的特征。
