Furusawa T, Hiratake Y, Mishina T, Ooe H, Maegawa M, Furudama H, Hida S, Itoh M, Inoue S, Nakagawa K
Department of Urology, Kyoto 2nd Red Cross Hospital.
Hinyokika Kiyo. 1994 Sep;40(9):853-60.
One hundred and fifty female patients with acute uncomplicated cystitis were given 200 mg of CPDX-PR twice daily for 3-7 days to evaluate both its overall clinical efficacy and its adverse effects. In 82 cases (Group I) in which it was administered for 3 days, the overall clinical efficacy, evaluated by the criteria proposed by the Japanese UTI committee, was excellent in 64 cases, moderate in 17 and poor in one, with the effective rate being 98.8%. In 35 cases (Group II) in which it was administered for 4-7 days, the overall clinical efficacy was excellent in 18 cases, moderate in 15 and poor in 2, with the effective rate being 94.3%. The overall clinical evaluation was not performed in another 33 cases because they were given CPDX-PR for more than 8 days or 300 mg/day. Subjective adverse effects such as hoarseness and lingual inflammation were observed in only one of the 150 cases, but they disappeared spontaneously after the cessation of administration of CPDX-PR. These findings suggest that CPDX-PR is one of the most effective and safe antibiotic in the treatment of acute uncomplicated cystitis.
对150例急性单纯性膀胱炎女性患者给予200mg丙帕他莫，每日2次，共3 - 7天，以评估其总体临床疗效和不良反应。在82例（I组）接受治疗3天的患者中，按照日本泌尿道感染委员会提出的标准评估，总体临床疗效为：64例优，17例中，1例差，有效率为98.8%。在35例（II组）接受治疗4 - 7天的患者中，总体临床疗效为：18例优，15例中，2例差，有效率为94.3%。另外33例未进行总体临床评估，因为他们接受丙帕他莫治疗超过8天或每日剂量为300mg。150例患者中仅1例出现诸如声音嘶哑和舌炎等主观不良反应，但在停止使用丙帕他莫后自行消失。这些结果表明，丙帕他莫是治疗急性单纯性膀胱炎最有效且安全的抗生素之一。
