Gordon F D, Anastopoulos H, Khettry U, Loda M, Jenkins R L, Lewis W D, Trey C
Department of Medicine, Deaconess Hospital, Boston, Massachusetts.
Am J Gastroenterol. 1995 Jan;90(1):117-20.
Fulminant hepatic failure is caused by a variety of viruses, toxins, and metabolic derangements. The hepatitis C virus (HCV) causes indolent development of cirrhosis and has not been associated with fulminant hepatic failure. We report the first documented case of fulminant hepatitis C in the United States. The patient developed jaundice and stage IV encephalopathy. Initial laboratory evaluation did not reveal the etiology. The patient survived without liver transplantation. Three wk later he was found to have a positive HCV RNA and anti-HCV antibody seroconversion. He continued to improve with alpha-interferon treatment and has normal liver function and a negative HCV RNA 15 months later.
暴发性肝衰竭由多种病毒、毒素和代谢紊乱引起。丙型肝炎病毒（HCV）导致肝硬化的缓慢发展，且与暴发性肝衰竭无关。我们报告了美国首例有记录的暴发性丙型肝炎病例。该患者出现黄疸和IV期肝性脑病。初始实验室评估未揭示病因。患者未经肝移植而存活。三周后，他被发现HCV RNA阳性且抗-HCV抗体血清学转换。他接受α-干扰素治疗后持续好转，15个月后肝功能正常且HCV RNA阴性。
