Osipova N A, Novikov G A, Vetsheva M S, Prokhorov B M, Beresnev V A, Loseva N A, Zemskaia S Iu, Smolina T A
Anesteziol Reanimatol. 1994 Jul-Aug(4):53-7.
Prosidol, a new Russian narcotic analgesic, was used in various dosage forms (buccal and oral tablets, injection solution) in 113 cancer patients for the treatment of chronic pain, as a component of total anesthesia, and for postoperative analgesia. The best results were attained with the universal noninvasive dosage form, buccal tablets, used for the treatment of chronic pain in incurable patients. Analgesic properties of buccal prosidol are close to those of tramadol, the drug is well tolerated by the patients and causes no grave side effects. As a drug for postoperative analgesia prosidol was highly effective in patients after extracavitary oncologic surgery and less effective after thoracal and abdominal interventions. As a component of total anesthesia prosidol is inferior to fentanyl and approximately similar to promedol. An advantage of prosidol is its highly effective universal noninvasive dosage form, buccal tablets, which may be used for rapid analgesia in any situation.
普罗西多，一种新型俄罗斯麻醉性镇痛药，以多种剂型（口腔含片和口服片剂、注射溶液）用于113例癌症患者，用于治疗慢性疼痛、作为全身麻醉的组成部分以及术后镇痛。通用的非侵入性剂型口腔含片用于治疗不治之症患者的慢性疼痛时取得了最佳效果。口腔含服普罗西多的镇痛特性与曲马多相近，患者对该药耐受性良好，且无严重副作用。作为术后镇痛药，普罗西多在腔外肿瘤手术后的患者中效果显著，而在胸腹部手术后效果较差。作为全身麻醉的组成部分，普罗西多不如芬太尼，与异丙嗪近似。普罗西多的一个优点是其高效的通用非侵入性剂型口腔含片，可在任何情况下用于快速镇痛。
