Osipova N A, Novikov G A, Ziai G R, Mel'nikova Z L
Anesteziol Reanimatol. 1990 Nov-Dec(6):55-8.
The study of 65 cancer patients has demonstrated the advantages and disadvantages of tramal as an agent used for the relief of acute and chronic pain syndrome. In 18 patients tramal was used in postoperative analgesia, in 17 patients it was used for the treatment of chronic pain syndrome. It has been shown that in the postoperative period tramal has no noticeable advantages over promedol. However, tramal had definite advantages over other opiate agonists when used for the treatment of chronic pain syndrome in incurable cancer patients. Thus, the data obtained show that tramal, a synthetic analgesic of a new generation, has no dangerous side effects, is effective in a convenient, non-invasive drug form, interacts well with non-narcotic and supplementary agents and causes no clinical signs of drug tolerance or addiction in prolonged application.
对65名癌症患者的研究表明了曲马多作为一种用于缓解急慢性疼痛综合征的药物的优缺点。18名患者使用曲马多进行术后镇痛,17名患者使用它治疗慢性疼痛综合征。结果显示,在术后阶段,曲马多相对于异丙嗪没有明显优势。然而,在治疗晚期癌症患者的慢性疼痛综合征时,曲马多相对于其他阿片类激动剂具有明确优势。因此,所获得的数据表明,新一代合成镇痛药曲马多没有危险的副作用,以方便、非侵入性的药物形式有效,与非麻醉性和辅助药物相互作用良好,长期使用不会产生药物耐受性或成瘾的临床迹象。