López A, Löfstedt J, Bildfell R, Horney B, Burton S
Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada.
Am J Vet Res. 1994 Sep;55(9):1303-7.
A study was conducted to investigate whether aspiration of amniotic fluid is associated with a deleterious effect on absorption of colostral immunoglobulins or on blood gas and acid-base values of healthy newborn calves. Fourteen calves purchased from commercial sources were transported to a research facility immediately after birth and fed colostrum with known concentrations of immunoglobulins. Blood samples for gas analyses were collected within 5 hours of birth, 24 hours later, and prior to euthanasia. Between 3 and 5 days of age, calves were euthanatized by an overdose of barbiturates. Eleven calves had evidence of bronchoaspiration of amniotic fluid, as determined by presence of meconium, squamous epithelium, or keratin in histologic sections of fixed lung or by cytologic analysis of bronchoalveolar lavage fluid. Blood gas tensions and pH were within reference ranges in 11 of 14 calves. Aspiration of amniotic fluid could not be linked to any specific changes in blood gas tensions, acid-base status, or absorption of colostral immunoglobulins. Presence of keratin and meconium in the lungs often was accompanied by mild exudative alveolitis and focal atelectasis. It was concluded that aspiration of small amounts of amniotic fluid with or without meconium is common in calves and is not associated with hypoxemia, respiratory acidosis, or failure of passive transfer.
开展了一项研究，以调查羊水吸入是否会对健康新生犊牛的初乳免疫球蛋白吸收或血气及酸碱值产生有害影响。从商业渠道购买的14头犊牛出生后立即被运至研究机构，并用已知免疫球蛋白浓度的初乳进行喂养。在出生后5小时内、24小时后以及安乐死之前采集用于气体分析的血样。在犊牛3至5日龄时，通过过量注射巴比妥酸盐使其安乐死。通过固定肺组织学切片中胎粪、鳞状上皮或角蛋白的存在，或支气管肺泡灌洗液的细胞学分析，确定11头犊牛有羊水支气管吸入的证据。14头犊牛中有11头的血气张力和pH值在参考范围内。羊水吸入与血气张力、酸碱状态或初乳免疫球蛋白吸收的任何特定变化均无关联。肺中角蛋白和胎粪的存在常伴有轻度渗出性肺泡炎和局灶性肺不张。研究得出结论，无论有无胎粪，少量羊水吸入在犊牛中很常见，且与低氧血症、呼吸性酸中毒或被动转运失败无关。
