Vecchioli Scaldazza C, Morosetti D
Departamento de Urología, Hospitales de Jesi, Italia.
Arch Esp Urol. 1994 Sep;47(7):671-3.
A retrospective review of 186 cases of transitional cell carcinoma of the bladder observed between 1987 and 1990 is described. Squamous metaplasia was present in 37 cases. This histological feature was especially found in association with poorly differentiated and invasive tumors: the presence of extensive areas of squamous metaplasia (metaplastic areas = or > 50% of neoplastic surface) was always found in association with high grade neoplasms. For these reasons the authors conclude that transitional cell carcinoma of the bladder showing squamous metaplasia is more aggressive than pure transitional cell carcinoma.
本文描述了对1987年至1990年间观察到的186例膀胱移行细胞癌病例的回顾性研究。37例存在鳞状化生。这种组织学特征尤其见于低分化和浸润性肿瘤：广泛鳞状化生区域（化生区域占肿瘤表面的50%或更多）的存在总是与高级别肿瘤相关。基于这些原因，作者得出结论，显示鳞状化生的膀胱移行细胞癌比单纯的膀胱移行细胞癌更具侵袭性。
