Frost A R, Terahata S, Yeh I T, Siegel R S, Overmoyer B, Silverberg S G
Department of Pathology, George Washington University Medical Center, Washington, DC 20037.
Arch Pathol Lab Med. 1995 Jan;119(1):64-8.
To determine the prognostic significance of signet ring cells in infiltrating lobular carcinomas, the percentage of signet ring cells in 99 infiltrating lobular carcinomas was correlated with the patients' clinical outcomes (mean follow-up interval of 4.8 years). When the carcinomas were divided into those with 0%, 1-9%, and 10% or more signet ring cells, 57% (26/46) of patients with 10% or more signet ring cells had experienced recurrences or metastases compared with 40% (2/5) and 31% (15/48) with 0% and 1-9%, respectively. A similar analysis performed with breakpoints at 20% or 30% failed to yield any statistically significant associations. When patients were stratified by pathologic stage, patients with stage I disease and 10% or more signet ring cells were more likely to have recurrences or metastases than those patients with stage I tumors and fewer than 10% signet ring cells. There was no relationship between signet ring cells and disease progression in stages II, III, and IV. These results indicate that the presence of 10% or more signet ring cells represents a poor individual prognostic factor in stage I infiltrating lobular carcinomas.
为了确定印戒细胞在浸润性小叶癌中的预后意义，对99例浸润性小叶癌中印戒细胞的百分比与患者的临床结局（平均随访间隔4.8年）进行了相关性分析。当将癌组织分为印戒细胞比例为0%、1%-9%以及10%及以上时，印戒细胞比例为10%及以上的患者中有57%（26/46）出现复发或转移，而印戒细胞比例为0%和1%-9%的患者中这一比例分别为40%（2/5）和31%（15/48）。以20%或30%为界点进行的类似分析未得出任何具有统计学意义的关联。当根据病理分期对患者进行分层时，I期疾病且印戒细胞比例为10%及以上的患者比I期肿瘤且印戒细胞比例低于10%的患者更易出现复发或转移。在II期、III期和IV期，印戒细胞与疾病进展之间没有关系。这些结果表明，印戒细胞比例为10%及以上是I期浸润性小叶癌中一个不良的个体预后因素。
