Bocklage T, Feddersen R
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.
Arch Pathol Lab Med. 1995 Jan;119(1):69-74.
Histological, immunohistochemical, and flow cytometric characteristics of three unusual parotid gland tumors are described. The patients were adult white men with carcinoma ex pleomorphic adenoma, true malignant mixed tumor, and primary parotid gland chondrosarcoma. The carcinoma ex pleomorphic adenoma showed evidence of simultaneous epithelial, myoepithelial, and mesenchymal differentiation by immunohistochemistry. The true malignant mixed tumor exhibited variable positivity for two keratins, vimentin, proliferating cell nuclear antigen, Ki67, and p53. The chondrosarcoma initially stained for vimentin, S100, muscle-specific actin, proliferating cell nuclear antigen, and Ki67, but it lost actin expression in its first recurrence, accompanied by more extensive Ki67 staining. DNA ploidy varied from diploid to aneuploid with intratumoral variation in the carcinosarcoma. S-phase fractions ranged from 2.43% to 13.9%. The findings underscore the diversity of tumors that may be pathogenetically related to, and at times derived from, pleomorphic adenoma.
本文描述了三种不常见腮腺肿瘤的组织学、免疫组织化学及流式细胞术特征。患者为成年白人男性，分别患有多形性腺瘤恶变、真性恶性混合瘤和原发性腮腺软骨肉瘤。多形性腺瘤恶变经免疫组织化学显示同时具有上皮、肌上皮和间充质分化的证据。真性恶性混合瘤对两种角蛋白、波形蛋白、增殖细胞核抗原、Ki67和p53呈不同程度阳性。软骨肉瘤最初对波形蛋白、S100、肌肉特异性肌动蛋白、增殖细胞核抗原和Ki67染色阳性，但在首次复发时失去肌动蛋白表达，同时Ki67染色范围更广。癌肉瘤的DNA倍体从二倍体到非整倍体不等，肿瘤内存在差异。S期分数范围为2.43%至13.9%。这些发现强调了可能与多形性腺瘤在发病机制上相关且有时起源于多形性腺瘤的肿瘤的多样性。
