Yoshikawa M, Arashidani K, Katoh T, Kawamoto T, Kodama Y
Division of Occupational Hygiene, School of Nursing and Medical Technology, University of Occupational and Environmental Health, Japan.
Arch Toxicol. 1994;68(8):517-9. doi: 10.1007/s002040050105.
The pulmonary elimination after intraperitoneal administration at three different doses (50, 100, and 500 mg/kg) of methyl tertiary-butyl ether (MTBE) was studied using mice. There were two exponential curves with an initial rapid decrease of the elimination ratio followed by a slow decrease at the doses of 100 mg/kg and 500 mg/kg. The calculated half-lives of the two elimination curves obtained by the least squares method were approximately 45 min and 80 min. The pulmonary elimination ratios at the three different doses were from 23.2% to 69.0%. Most of the excreted MTBE was eliminated within 3 h. It is suggested in this paper that MTBE in exhaled air can be used as a biological exposure index for the exposure assessment of MTBE.
使用小鼠研究了腹腔注射三种不同剂量（50、100和500毫克/千克）甲基叔丁基醚（MTBE）后的肺部排泄情况。在100毫克/千克和500毫克/千克剂量下，有两条指数曲线，消除率最初迅速下降，随后缓慢下降。通过最小二乘法获得的两条消除曲线的计算半衰期约为45分钟和80分钟。三种不同剂量下的肺部消除率为23.2%至69.0%。大部分排泄的MTBE在3小时内被消除。本文提出，呼出空气中的MTBE可作为MTBE暴露评估的生物暴露指标。
