Katoh T, Arashidani K, Kikuchi M, Yoshikawa M, Kodama Y
School of Nursing and Medical Technology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Nihon Eiseigaku Zasshi. 1993 Oct;48(4):873-8. doi: 10.1265/jjh.48.873.
The effect of one-shot or repeated treatment with methyl tertiary-butyl ether (MTBE) on lipid peroxidation and cytochrome P-450 in mouse liver was examined. One-shot treatment at the 500 mg/kg dose level caused a transient decrease in leukocyte number after 24 h. An increased level of lipid peroxide was observed in the liver homogenates 24 h after one-shot treatment and four weeks of repeated 200 mg/kg treatment. The hepatic cytochrome P-450 content increased after one and four weeks of repeated treatment (50, 200 mg/kg). On the other hand, the treatment did not affect glutathione content and glutathione-S-transferase activity. These results indicate that MTBE treatment caused lipid peroxidation in the liver homogenate and induction of hepatic microsomal cytochrome P-450 content.
研究了单次或重复给予甲基叔丁基醚（MTBE）对小鼠肝脏脂质过氧化和细胞色素P-450的影响。500mg/kg剂量水平的单次给药在24小时后导致白细胞数量短暂减少。单次给药24小时后以及重复给予200mg/kg剂量四周后，肝脏匀浆中脂质过氧化物水平升高。重复给药（50、200mg/kg）一周和四周后，肝脏细胞色素P-450含量增加。另一方面，该处理不影响谷胱甘肽含量和谷胱甘肽-S-转移酶活性。这些结果表明，MTBE处理导致肝脏匀浆中脂质过氧化并诱导肝脏微粒体细胞色素P-450含量增加。
