Matsuda M, Miyagi K, Yanagisawa N, Tsukada N
Department of Medicine (Neurology), Shinshu University School of Medicine.
Arerugi. 1994 Sep;43(9):1215-9.
Several kinds of immunological abnormalities have been found more frequently in patients with subacute myelo-optico-neuropathy (SMON). To investigate whether the B-cell immune system is implicated in aging in patients with SMON, we examined serum levels of immunoglobulin including IgG, IgM, and IgA, and the number of CD20+ cells (B lymphocytes) and CD20+ CD23+ cells (activated B lymphocytes) using flow cytometry, and compared them with those in age-matched controls. We also investigated whether the number of HLA-DR+ cells was correlated with those of CD20+ cells, CD20+ CD23+ cells, or HLA-DR+CD3+ cells (activated T lymphocytes) in patients with SMON. Serum levels of IgG, IgM and IgA were decreased with aging both in the patients with SMON and in the controls, and no significant difference was found between the two groups. Although the patients with SMON tended to show higher levels of CD20+ and CD20+ CD23+ cells than the age-matched controls, there were no significant differences between the two groups. The number of HLA-DR+ cells was correlated not with that of CD20+ cells or CD20+ CD23+ cells, but with that of HLA-DR+CD3+ cells. In patients with SMON, it is likely that the B-cell immune system is mainly implicated in the effect of aging, but it is unlikely that other factors than aging are associated with the B-cell immune system. The increase in the number of HLA-DR+ cells associated with aging in patients with SMON reflects the increase in the number of activated T lymphocytes, and is not correlated with the changes of B lymphocytes.
在亚急性脊髓视神经病（SMON）患者中，几种免疫异常情况更为常见。为了研究B细胞免疫系统是否与SMON患者的衰老有关，我们使用流式细胞术检测了包括IgG、IgM和IgA在内的免疫球蛋白血清水平，以及CD20+细胞（B淋巴细胞）和CD20+ CD23+细胞（活化B淋巴细胞）的数量，并将其与年龄匹配的对照组进行比较。我们还研究了SMON患者中HLA-DR+细胞的数量是否与CD20+细胞、CD20+ CD23+细胞或HLA-DR+CD3+细胞（活化T淋巴细胞）的数量相关。SMON患者和对照组中，IgG、IgM和IgA的血清水平均随年龄增长而降低，两组之间未发现显著差异。尽管SMON患者的CD20+和CD20+ CD23+细胞水平往往高于年龄匹配的对照组，但两组之间没有显著差异。HLA-DR+细胞的数量与CD20+细胞或CD20+ CD23+细胞的数量无关，而是与HLA-DR+CD3+细胞的数量相关。在SMON患者中，B细胞免疫系统可能主要与衰老的影响有关，但除衰老外的其他因素不太可能与B细胞免疫系统相关。SMON患者中与衰老相关的HLA-DR+细胞数量增加反映了活化T淋巴细胞数量的增加，并且与B淋巴细胞的变化无关。
