Nishi M, Takeshima H, Mori M, Nakagawara K, Takeuchi T
Department of Neurochemistry, Tokyo Institute of Psychiatry, Japan.
Biochem Biophys Res Commun. 1994 Dec 15;205(2):1353-7. doi: 10.1006/bbrc.1994.2814.
Recent cDNA cloning studies have defined four members of the opioid receptor family, i.e., delta-, mu- and kappa-subtypes, and an opioid receptor homologue for unknown ligands. In this report, we isolated and analyzed mouse genomic DNA segments containing the kappa-opioid receptor gene and a gene for the opioid receptor homologue (designated as MOR-C). The genes are closely related each other in exon-intron organization, suggesting their evolutional relationship. Using in situ hybridization, we show that the kappa-opioid receptor gene and the MOR-C gene map to mouse chromosome 1A2-3 and 2H2-4, respectively.
最近的cDNA克隆研究已经确定了阿片受体家族的四个成员，即δ、μ和κ亚型，以及一种针对未知配体的阿片受体同源物。在本报告中，我们分离并分析了包含κ-阿片受体基因和阿片受体同源物基因（命名为MOR-C）的小鼠基因组DNA片段。这些基因在外显子-内含子组织上彼此密切相关，表明它们之间存在进化关系。通过原位杂交，我们发现κ-阿片受体基因和MOR-C基因分别定位于小鼠染色体1A2-3和2H2-4。
