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Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex.

作者信息

Sohda M, Misumi Y, Fujiwara T, Nishioka M, Ikehara Y

机构信息

Department of Biochemistry, Fukuoka University School of Medicine, Japan.

出版信息

Biochem Biophys Res Commun. 1994 Dec 15;205(2):1399-408. doi: 10.1006/bbrc.1994.2821.

DOI:10.1006/bbrc.1994.2821
PMID:7802676
Abstract

Autoantibodies from a patient with chronic rheumatoid arthritis recognized an antigen localized in the Golgi complex of various cells from different tissues and species. The autoantibodies were used as a probe for screening human QGP-1 cDNA library, resulting in identification of a 10.3-kb cDNA. The cDNA insert contained an open reading frame which encodes a 3225-residue protein with a calculated mass of 372 kDa. The predicted protein was found to have no NH2-terminal signal sequence but a single hydrophobic domain at the COOH terminus. These results indicate that the 372-kDa antigen is cytoplasmically disposed and anchored to the Golgi membrane by the COOH-terminal hydrophobic domain.

摘要

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