幽门螺杆菌唾液抗体：在内镜检查前筛查消化不良患者

Salivary antibodies to Helicobacter pylori: screening dyspeptic patients before endoscopy.

作者信息

Patel P, Mendall M A, Khulusi S, Molineaux N, Levy J, Maxwell J D, Northfield T C

机构信息

Department of Medicine, St George's Hospital Medical School, London, UK.

出版信息

Lancet. 1994 Aug 20;344(8921):511-2. doi: 10.1016/s0140-6736(94)91899-6.

DOI:10.1016/s0140-6736(94)91899-6

PMID:7802777

Abstract

Diagnostic tests on saliva have advantages compared with those on serum. In 119 consecutive dyspeptic patients referred for endoscopy we developed and validated an enzyme-linked immunosorbent assay to detect salivary immunoglobulins to Helicobacter pylori. Salivary IgG distinguished positive and negative cases (p < 0.0001), but salivary IgA did not. The optimum performance of salivary IgG (85%) was similar to that of serum IgG (90%) and better than that of salivary IgA. Using our assay and a history of regular use of non-steroidal anti-inflammatories in screening patients under 45 years, we detected all peptic ulcers while saving 39% of endoscopies.

摘要

与血清检测相比，唾液诊断测试具有优势。在119例连续转诊接受内镜检查的消化不良患者中，我们开发并验证了一种酶联免疫吸附测定法，以检测唾液中针对幽门螺杆菌的免疫球蛋白。唾液IgG能够区分阳性和阴性病例（p < 0.0001），但唾液IgA不能。唾液IgG的最佳性能（85%）与血清IgG（90%）相似，且优于唾液IgA。在对45岁以下患者进行筛查时，使用我们的检测方法并结合非甾体抗炎药的常规使用史，我们检测出了所有消化性溃疡，同时节省了39%的内镜检查。